Amino Up Chemical Co.,Ltd
A unique culture for better health
Since 1984 ,Amino Up chemical has been developing unique nutraceuticals and functional food in-gredients with health and clinical benefits. Its flagship active hexose correlated compound-a mushroom extract-is attracting intense international interest as a preventative and complementary therapy for cancer, as well as a potential treatment for human papillomavirus.
“Our focus at Amino up is to develop and manufacture unique ingredients with the potential for real health benefits, explains kohei Homma, director and senior manager of research and development.” The ingredients we discover are new and unknown, and so we also carry out our own extensive research to accumulate the scientific evidence needed to satisfy users of our products and to demonstrate their clinical effectiveness. We call it evidencebased nutritional immunotherapy.”
A long-established biotechnology company, Amino Up has assembled an impressive repertoire of physiologically active nutraceuticals, including a high-efficacy polyphenol antioxidant called Oligonol, a perilla extract with anti-allergy, antiasthma, and anti-inflammatory activity, as well as a potentially potent anti-tumour ingredient derived from soy and mushroom culture called genistein combined polysaccharide (GCP),and an anti-stress ingredient extracted from asparagus, among a number of others. The health benefits of these products are supported by over 80 scientific publications including clinical data. But it is Amino Up’s active hexose correlated compound (AHCC) product that has proved to be the most promising and of greatest to clinicians.
“We discovered AHCC more than 25 years ago after screening hundreds of different mushroom species to find those with the potential to stimulate the immune systems,” says Homma. “We found one species stood out from all the others. We then found that we could enhance and isolate the beneficial component by culturing just the filamentous mycelia of the mushroom in liquid. It is a long process, taking about 2 months, but the final AHCC product has some unique properties, including a strongly stimulating effect on the immune system.”
Although AHCC has many promising applications as an immunostimulant, its role as a complementary and preventative therapy for cancer has attracted the most interest. “AHCC has been used for many years now as a complementary nutraceutical to ease the side-effects of chemotherapy and radiation therapy for cancer patients,” says Homma. “In these patients with suppressed immune function,AHCC lowers the risk of secondary infection and the generation of new cancers, as well as being an anti-inflam-matory and having a beneficial effect on intestinal flora.”
Amino Up has received preliminary results from the University of Ottawa showing that AHCC might suppress the proliferation of cancer stem cells-a root cause implicated in most cancers—by affecting the transcription of microRNA, which could have wide-reaching implications in cancer treatment. Recent preclinical studies have also indicated that AHCC might be an effective treatment for human papillomavirus (HPV),which is responsible for 99% of cervical cancers, achieving full eradication of HPV in 50% of a small group of chronically HPV-positive patients. These promising results have led to a much larger clinical study at the University of Texas, along with other trials in ltaly, Bulgaria and Thailand.
“To maintain health and reduce the global costs of healthcare in the future, nutritional approaches like AHCC will become increasingly important,” continues Homma. “We are beginning to accumulate a lot of scientific evidence that shows that AHCC can be tremendously effective in a clinical setting as well as being very useful for improving and maintaining health.”
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Amino Up Chemical
Contact
Tel: +81 11 889 2299
Website: www.aminoup.co.jp
翻译
阿明诺化学株式会社
独特的健康文化
自1984年以来，阿明诺化学一直在开发独特的营养保健品，并在全球引领临床最前沿的功能性食品。其旗舰产品活化糖类相关化合物——蘑菇提取物，正吸引着全球性的关注，尤其在预防和辅助治疗癌症，特别是对人类乳头状瘤病毒的彻底治疗有独特的贡献。
“阿明诺重点是开发和生产对健康有益的独特成分”，研发高级经理本间康平博士解释说，“我们发现该成分是新的，未知的，在这一方面我们积累了大量的数据，并证明其临床疗效。我们称之为循证营养免疫疗法。”
一个历史悠久的生物技术公司，阿明诺已经生产出具有生理活性的保健食品，其中包括被称为Oligonol具有抗氧化功能的小分子多酚；和具有抗过敏，抗哮喘和抗炎活性紫苏提取物等令人印象深刻的产品；以及从大豆和蘑菇中提取的被称为异黄酮结合多糖（GCP）衍生的强效抗肿瘤成分；以及从芦笋中提取的一种抗压力的成分。这些产品对健康的好处已超过80部科学出版物包括临床数据的支持。包括已被证明是最有临床价值的活化糖类相关化合物（AHCC）。
本间说，“25年前，我们筛选几百种不同的蘑菇品种，寻找具有潜力的可刺激免疫系统的品种，然后发现AHCC，我们发现这个优异的物种。可以通过培养在液体蘑菇的菌丝体丝状态中分离出有益成分。它是一个漫长的过程，需要大约2个月， AHCC产品具有独特的性能，包括对免疫系统的强效刺激作用”。
作为免疫刺激剂AHCC具有广阔的前景，其中作为癌症的预防和治疗作用已经吸引了全球的关注。 “AHCC已使用了许多年，现在作为补充营养药物，以减轻化疗和放疗的副作用，”本间说。 “以这些患者免疫功能抑制，AHCC降低二次感染的危险性和新的癌症的产生，以及作为抗炎作用对肠道益生菌群的生长具有很好的效果。”
阿明诺已收到来自渥太华大学的研究表明，AHCC可能影响癌症的microRNA的转录，这可能在癌症治疗中抑制肿瘤干细胞，切断干细胞的增殖。最近临床前的研究也表明，AHCC对治疗人乳头瘤病毒（HPV）的感染有效，对HPV阳性的患者50％有效。99％的子宫颈癌由这种病毒导致，更大规模的临床研究在得克萨斯大学，在意大利，保加利亚和泰国正在进行中。
“为了保持健康，减少在未来医疗保健的全球成本，像AHCC营养的方法将变得越来越重要，”本间说，“我们开始积累了大量的科学证据表明，AHCC在临床辅助治疗中极其有效，以及对保持健康状态也非常有用。”
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阿明诺化学
联系方式
联系电话：+81 11 889 2299
网址：www.aminoup.co.jp
